Role of VEGF Signaling Pathway in Pathological Mechanism of Colorectal Cancer and Traditional Chinese Medicine Intervention： A Review
10.13422/j.cnki.syfjx.20241642
- VernacularTitle:VEGF信号通路在结直肠癌病理机制中的作用及中医药干预研究现状
- Author:
Qiuning LIU
1
;
Yutian ZHU
2
;
Yun XU
3
;
Yang YE
2
;
Xiaoqiang JIA
3
Author Information
1. Beijing University of Chinese Medicine， Beijing 100029，China
2. Peking University Third Hospital， Beijing 100191， China
3. Xiyuan Hospital， China Academy of Chinese Medical Sciences， Beijing 100091，China
- Publication Type:Journal Article
- Keywords:
vascular endothelial growth factor （VEGF）;
signaling pathway;
colorectal tumor;
molecular mechanism;
traditional Chinese medicine
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2025;31(9):289-296
- CountryChina
- Language:Chinese
-
Abstract:
Colorectal cancer is a malignant tumor that originates from the epithelial cells of the colon and rectum. It has the third highest incidence and the second highest mortality rate among malignant tumors worldwide. With the rapid development of the economy and the increasing Westernization of dietary habits in China， its incidence in China has been rising year by year. Over the past decade， despite the introduction of numerous treatment methods for colorectal cancer， the efficacy of existing therapies remains unsatisfactory. In recent years， traditional Chinese medicine （TCM） has become a major focus in the treatment of colorectal cancer due to its advantages of multi-target， multi-pathway mechanisms and low toxicity and side effects. Vascular endothelial growth factor （VEGF） is an important angiogenic factor that promotes blood vessel formation， providing nutrients and oxygen for tumor growth. It also increases vascular permeability， allowing tumor cells to easily pass through the blood vessel wall into other tissues， thereby facilitating metastasis. Several studies have shown that TCM can inhibit tumor angiogenesis and lymphangiogenesis， promote tumor cell apoptosis， and inhibit the proliferation of colorectal cancer cells by acting on the VEGF signaling pathway， thereby delaying tumor growth. In recent years， research in this field has been rapidly updated， but there is a lack of relevant summaries， making subsequent literature searches inconvenient. Therefore， this article focuses on the physiological functions of the VEGF signaling pathway， its role in the occurrence of colorectal cancer， and the intervention of TCM on VEGF， providing a supplement and summary of relevant information to offer a reference for future research in this area.
