Mechanism of Chinese Medicine Polysaccharide in Improving Myocardial Ischemia-reperfusion Injury
10.13422/j.cnki.syfjx.20241921
- VernacularTitle:中药多糖改善心肌缺血再灌注损伤的作用机制
- Author:
Siqing WU
1
;
Mingsan MIAO
1
;
Jinxin MIAO
1
Author Information
1. Henan University of Chinese Medicine， Zhengzhou 450046， China
- Publication Type:Journal Article
- Keywords:
Chinese medicine polysaccharide;
myocardial ischemia-reperfusion injury;
anti-inflammatory;
anti-apoptosis;
anti-oxidation
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2025;31(9):277-288
- CountryChina
- Language:Chinese
-
Abstract:
Myocardial ischemia-reperfusion injury （MIRI） is one of the major complications of cardiovascular diseases in recent years， seriously threatening the life and health of patients. In recent years， although significant progress has been made in modern medical research on MIRI， due to its complex pathogenesis， adverse drug reactions， and high postoperative risks， there is an urgent need for safer and more effective therapeutic drugs. The pathological effects of MIRI involve inflammatory responses， oxidative stress， apoptosis， and other mechanisms， while Chinese medicine polysaccharide compounds exhibit pharmacological effects such as anti-inflammation， antioxidation， and anti-apoptosis， which are of great significance for improving MIRI. Numerous studies have found that Chinese medicine polysaccharide compounds mainly exert their effects by activating signal pathways such as nerve regenerative factor-1/epidermal growth factor receptor （NRG-1/ErbB）， phosphatidylinositol-3-kinase/protein kinase B （PI3K/Akt）， nuclear factor E2-related factor 2/heme oxygenase-1 （Nrf2/HO-1）， adenosine 5ʹ-monophosphate-activated protein kinase/silent information regulator 1/peroxisome proliferators-activated receptor γ coactivator lα （AMPK/SIRT1/PGC1α）， Ras homologous gene/Rho kinase （Rho/ROCK）， glycogen synthase kinase 3 （GSK-3）， and P38 mitogen-activated protein kinase （p38-MAPK）， thereby playing a role in improving MIRI. This paper， based on an extensive review of relevant literature in China and abroad， systematically summarizes the latest research findings on the use of Chinese medicine polysaccharide compounds in the treatment of MIRI， analyzes the mechanisms by which these compounds improve MIRI， and explores new therapeutic directions based on the joint investigation of signaling pathways and metabolomics. The paper emphasizes the importance of interdisciplinary cooperation in promoting the development of new drugs， aiming to provide valuable references for the basic research and clinical application of Chinese medicine polysaccharide compounds， ultimately benefiting the majority of cardiovascular disease patients.
