Clinical Efficacy of Tongfu Kuanzhong Decoction on Constipation-predominant Irritable Bowel Syndrome and Its Effect on Colonic Dynamics
10.13422/j.cnki.syfjx.20242428
- VernacularTitle:通腑宽中汤治疗便秘型肠易激综合征的疗效观察及对结肠动力学的影响
- Author:
Junwei LIANG
1
;
Wenjun BAI
2
;
Zu GAO
3
;
Dajuan SUN
1
Author Information
1. First Clinical Medical College， Shandong University of Traditional Chinese Medicine（TCM）， Jinan 250014， China
2. Affiliated Hospital of Shandong University of TCM， Jinan 250014， China
3. College of TCM， Shandong University of TCM， Jinan 250355， China
- Publication Type:Journal Article
- Keywords:
Tongfu Kuanzhong decoction;
constipation-predominant irritable bowel syndrome;
anxiety and depression;
anorectal manometry;
colonic electrical activity
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2025;31(9):150-156
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo observe the clinical efficacy of Tongfu Kuanzhong decoction （TFKZ） in the treatment of constipation-predominant irritable bowel syndrome （IBS-C） with spleen deficiency and Qi stagnation and its effects on anorectal manometry and colonic electrical activity parameters. MethodsSixty-four patients with IBS-C of the spleen deficiency and Qi stagnation type were included as research subjects and were randomized into the observation group （thirty-two cases） and control group （thirty-two cases）. The control group was orally administered mosapride citrate tablets， and the observation group was orally administered TFKZ. Both groups were treated for 4 weeks. The traditional Chinese medicine （TCM） syndrome scores， patient assessment of constipation symptoms （PAC-SYM） score， general anxiety disorder-7 （GAD-7） score， patient health questionnaire-9（PHQ-9）score， anorectal manometry， and colonic electrical activity parameters were observed before and after treatment in the two groups. ResultsThe total points of TCM syndromes were significantly lower in both groups after treatment （P<0.01） and lower in the observation group （P<0.05）. The fecal symptoms， rectal symptoms， abdominal symptoms， and total symptom scores of the patients in both groups were significantly decreased after treatment （P<0.01）， and the rectal symptoms， abdominal symptoms， and total symptom scores of the observation group were lower （P<0.05，P<0.01）. In both groups， the forced anal residual pressure and the initial rectal sensation threshold decreased after treatment （P<0.05，P<0.01）， and forced anal residual pressure in the control group was lower （P<0.01）. After treatment， the GAD-7 and PHQ-9 scores of patients in both groups decreased significantly （P<0.01）， and the GAD-7 score of the observation group was significantly lower （P<0.01）. After treatment， the average wave amplitude at different time points of each lead increased significantly in both groups， compared with that before treatment （P<0.01）. The average wave amplitude of each lead of the ascending colon， descending colon， sigmoid colon， and rectum in the observation group at 5 min before the meal and 10 min after the meal， as well as that of the ascending colon and rectum at 20 min and 30 min after the meal， was higher than that of the control group （P<0.05）. ConclusionTFKZ is effective in the treatment of IBS-C. Its mechanism may be related to the regulation of colonic function by down-regulating the forced anal residual pressure and the initial rectal sensation threshold and up-regulating the amplitude and frequency of intestinal electrical activity in each intestinal segment of the colon.
