Effect of Modified Wendantang on Serum 5-HT， MT， TNF-α， and Sex Hormone Levels in Patients with Perimenopausal Insomnia of Phlegm Heat Type
10.13422/j.cnki.syfjx.20242327
- VernacularTitle:加味温胆汤对围绝经期失眠痰热型患者血清5-HT、MT、TNF-α及性激素水平的影响
- Author:
Yan WANG
1
;
Yuexia XU
2
;
Wei DING
1
Author Information
1. The First Affiliated Hospital of Nanjing Medical University， Nanjing 210000， China
2. Nanjing Changjiang Hospital， Nanjing 210000， China
- Publication Type:Journal Article
- Keywords:
modified Wendantang;
perimenopausal insomnia;
phlegm heat type;
neurotransmitters;
melatonin （MT）;
tumor necrosis factor-α （TNF-α）;
sex hormones;
sleep quality
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2025;31(9):12-18
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo explore the application value of modified Wendantang in the treatment of perimenopausal insomnia of phlegm heat type and observe its effects on neurotransmitters and body fat. MethodsA total of 162 patients with perimenopausal insomnia of phlegm heat type who were treated in the Traditional Chinese Medicine Department of The First Affiliated Hospital with Nanjing Medical University from May 2021 to November 2023 were randomly divided into two groups before inclusion in the study. The control group of 81 cases received conventional Western medicine treatment， while the observation group of 81 cases received combined treatment with modified Wendantang， and the treatment lasted for 4 weeks. ResultsInterleukin-β （IL-1β）， and tumor necrosis factor alpha （TNF-α） decreased， while serum dopamine （DA）， melatonin （MT） and serotonin （5-HT） increased in both groups after treatment compared with before treatment （P<0.05）. After treatment， compared with the control group， the observation group showed better improvement in the above indicators （P<0.05）. The levels of follicle stimulating hormone （FSH） and luteinizing hormone （LH） decreased， while the level of estradiol （E2） increased in both groups after treatment compared with before treatment （P<0.05）. Compared with the control group， the observation group showed better improvement in the above sex hormone indicators after treatment （P<0.05）. The rapid eye movement sleep period （REM） and total sleep time （TST） were prolonged， and the sleep latency （SL） was shortened in the two groups after treatment compared with before treatment （P<0.05）. Compared with the control group， the observation group showed better improvement in sleep conditions after treatment （P<0.05）. The Pittsburgh sleep quality index （PSQI） and Traditional Chinese Medicine （TCM） total symptom score decreased significantly in both groups after treatment compared with before treatment （P<0.05）. Compared with the control group， the observation group showed better improvement in PSQI and TCM total symptom score after treatment （P<0.05）. The total effective rate of the observation group was 93.83% （76/81）， while that of the control group was 82.72% （67/81）， and the two had a statistically significant difference （χ2=9.135， P<0.05）. ConclusionFor patients with perimenopausal insomnia of phlegm heat type， the application of modified Wendantang can help regulate neurotransmitters and inflammatory factor levels， improve sex hormone levels， enhance sleep quality， and improve therapeutic effects.
