Mechanism research progress of traditional Chinese medicine in the intervention of Parkinson’s disease by regulating the Nrf2/HO-1 signaling pathway
- VernacularTitle:中药调控Nrf2/HO-1信号通路干预帕金森病的机制研究进展
- Author:
Jialin YAO
1
,
2
;
Lufeng BAI
3
;
Yunxiang GUAN
1
;
Baicheng QIAN
1
;
Baoliang WANG
1
Author Information
1. Encephalopathy Center，the First Affiliated Hospital of Henan University of Chinese Medicine，Zhengzhou 450099，China
2. The First Clinical Medical College，Henan University of Chinese Medicine，Zhengzhou 450046，China
3. Internal Medicine Ward 1，Nanyang Zhang Zhongjing Hospital，Henan Nanyang 473007，China
- Publication Type:Journal Article
- Keywords:
Parkinson’s disease;
traditional Chinese medicine;
Nrf2/HO-1 signaling pathway
- From:
China Pharmacy
2025;36(6):764-768
- CountryChina
- Language:Chinese
-
Abstract:
Parkinson’s disease （PD） is a common chronic neurodegenerative disease with movement disorders as the main clinical manifestation. The nuclear factor-erythroid 2-related factor 2 （Nrf2）/heme oxygenase-1 （HO-1） signaling pathway is closely associated with the occurrence and progression of PD. TCM flavonoid monomers （luteolin， rutin， etc.）， alkaloids （camptothecin， sinomenine， and alkaloids extracted from Uncaria rhynchophylla）， terpenes （tanshinone ⅡA， carvacrol， paeoniflorin）， phenols （ellagic acid， rosmarinic acid）， saponins （ginsenoside RK1）， and traditional Chinese medicine compounds （Wuzi yanzong pill and PD formula-2） can resist oxidative stress damage， inhibit inflammatory responses and abnormal aggregation of α-synuclein， and regulate neurotrophic factors by activating the Nrf2/HO-1 signaling pathway， thereby alleviating dopaminergic neuronal damage.
