Pharmacokinetic study of 3 blood-absorbed components of Xiangshao sanjie oral liquid in rats with hyperplasia of mammary gland
- VernacularTitle:香芍散结口服液3种入血成分在乳腺增生症模型大鼠体内的药动学研究
- Author:
Yu ZHANG
1
,
2
;
Jiaming LI
2
;
Dan PENG
2
;
Ruoqiu FU
2
;
Yue MING
2
;
Zhengbi LIU
3
;
Jingjing WANG
2
;
Shiqi CHENG
2
;
Hongjun XIE
1
;
Yao LIU
1
Author Information
1. School of Medicine，Tibet University，Lhasa 850011，China
2. Dept. of Pharmacy，Army Medical Center of PLA，Chongqing 400042，China
3. Laboratory Animal Center，Army Medical Center of PLA，Chongqing 400042，China
- Publication Type:Journal Article
- Keywords:
Xiangshao sanjie oral liquid;
hyperplasia of
- From:
China Pharmacy
2025;36(6):680-685
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To explore the pharmacokinetic characteristics of 3 blood-absorbed components of Xiangshao sanjie oral liquid in rats with hyperplasia of mammary gland （HMG）. METHODS Female SD rats were divided into control group and HMG group according to body weight， with 6 rats in each group. The HMG group was given estrogen+progesterone to construct HMG model. After modeling， two groups were given 1.485 g/kg of Xiangshao sanjie oral liquid （calculated by crude drug） intragastrically， once a day， for 7 consecutive days. Blood samples were collected before the first administration （0 h）， and at 5， 15， 30 minutes and 1， 2， 4， 8， 12， 24 hours after the last administration， respectively. Using chlorzoxazone as the internal standard， the plasma concentrations of ferulic acid， paeoniflorin and rosmarinic acid in rats were detected by UPLC-Q/TOF-MS. The pharmacokinetic parameters [area under the drug time curve （AUC0－24 h， AUC0－∞）， mean residence time （MRT0－∞）， half-life （t1/2）， peak time （tmax）， peak concentration （cmax）] were calculated by the non-atrioventricular model using Phoenix WinNonlin 8.1 software. RESULTS Compared with the control group， the AUC0－24 h， AUC0－∞ and cmax of ferulic acid in the HMG group were significantly increased （P＜0.05）； the AUC0－24 h， AUC0－∞ ， MRT0－∞ ， t1/2 and cmax of paeoniflorin increased， but there was no significant difference between 2 groups （P＞0.05）； the AUC0－24 h and MRT0-∞ of rosmarinic acid were significantly increased or prolonged （P＜0.05）. C ONCLUSIONS In HMG model rats， the exposure of ferulic acid， paeoniflorin and rosmarinic acid in Xiangshao sanjie oral liquid all increase， and the retention time of rosmarinic acid is significantly prolonged.
