Mechanism of action of bile-gut axis in the development and progression of intrahepatic cholangiocarcinoma

Xue YU; Tianhao Shen; Cheng Zhou; Yu Liu; Wei LI; Tinghui Jiang; Yongqiang Zhu; Yan Liu

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Mechanism of action of bile-gut axis in the development and progression of intrahepatic cholangiocarcinoma

VernacularTitle:胆-肠轴在肝内胆管癌发生发展中的作用机制
Author: Xue YU ¹ ; Tianhao SHEN ¹ ; Cheng ZHOU ¹ ; Yu LIU ¹ ; Wei LI ² ; Tinghui JIANG ¹ ; Yongqiang ZHU ¹ ; Yan LIU ¹
Author Information

1. Department of Interventional Oncology, Putuo Hospital Shanghai University of Traditional Chinese Medicine， Shanghai 200062， China
2. Department of Hepatobiliary Minimally Invasive Surgery, Putuo Hospital Shanghai University of Traditional Chinese Medicine， Shanghai 200062， China
Publication Type:Review
Keywords: Cholangiocarcinoma; Bile-Gut Axis; Gastrointestinal Microbiome; Bile Salt Metabolism; Inflammation
From: Journal of Clinical Hepatology 2025;41(3):588-593
CountryChina
Language:Chinese
Abstract: Intrahepatic cholangiocarcinoma is a malignant tumor with an extremely poor prognosis， and its pathogenesis is complex and remains unclear. In recent years， more and more studies have focused on the role of bile-gut axis in the development and progression of intrahepatic cholangiocarcinoma. Bile-gut axis refers to the complex interaction between bile and gut microbiota， including bile salt metabolism， dynamic changes of microbiota， inflammatory response， and immune system regulation. This article elaborates on the potential mechanisms of bile-gut axis in intrahepatic cholangiocarcinoma， especially gut microbiota dysbiosis， abnormal bile salt metabolism， chronic inflammatory response， and immune system interaction， this article aims to provide new perspectives and possible therapeutic targets for future research and promote the early diagnosis and effective treatment of intrahepatic cholangiocarcinoma.