Interpretation of metabolic dysfunction and alcohol-related liver disease： Position statement by an expert panel on alcohol-related liver disease （2024 edition）
- VernacularTitle:《2024年国际酒精相关肝病专家小组立场声明：代谢功能障碍和酒精相关性肝病》解读
- Author:
Zhenyao JIANG
1
;
Binbin ZHANG
1
;
Jie LI
2
;
Junping SHI
1
Author Information
- Publication Type:Journal Article
- Keywords: Metabolic Dysfunction and Alcohol-Related Liver Disease; Diagnosis; Therapeutics; Consensus
- From: Journal of Clinical Hepatology 2025;41(3):442-445
- CountryChina
- Language:Chinese
- Abstract: In November 2024， the Expert Group on Alcohol-related Liver Disease released a position statement on metabolic dysfunction and alcohol-related liver disease （MetALD）. MetALD is a new subtype of steatotic liver disease and refers to MASLD patients with a relatively large amount of alcohol consumption. The position statement points out the importance of accurate evaluation of alcohol consumption and recommends to quantify alcohol consumption using standard methods and alcohol biomarkers， and a comprehensive diagnosis should be made based on metabolic risk factors. In addition， the position statement analyzes the influence of drinking pattern on the diagnosis of MetALD and recommends to consider long-term drinking history during typing. The position statement also discusses the complex association between drinking and the diseases including metabolic syndrome， hepatic steatosis， fibrosis， and type 2 diabetes mellitus， and it is pointed out that the hierarchical management of patients should be optimized based on liver histological models and noninvasive models. The position statement elaborates on the definition of MetALD， drinking assessment， the interaction between alcohol use and metabolic dysfunction， and the methods for comprehensive management of MetALD， in order to facilitate learning and provide guidance for clinicians and researchers in clinical practice.
