Research progress on the mechanism of action of rosmarinic acid in the prevention of cardiovascular diseases
10.16438/j.0513-4870.2024-1027
- VernacularTitle:迷迭香酸在心血管疾病防治中的作用机制研究进展
- Author:
Ke CAI
1
;
Sheng-ru HUANG
1
;
Fang-fang GAO
1
;
Xiu-juan PENG
2
,
3
;
Sheng GUO
1
;
Feng LIU
2
,
3
;
Jin-ao DUAN
1
;
Shu-lan SU
1
Author Information
1. Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Jiangsu Key Laboratory for High Technology Research of TCM Formulae, National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, Nanjing
2. Shaanxi Institute of International Trade &
3. Commerce, Xianyang
- Publication Type:Research Article
- Keywords:
rosmarinic acid;
cardiovascular;
anti-inflammatory;
antioxidant;
antiplatelet aggregation;
anticoagulation;
protection of endothelial function
- From:
Acta Pharmaceutica Sinica
2025;60(1):12-21
- CountryChina
- Language:Chinese
-
Abstract:
With the rapid development of social economy and the continuous improvement of human living standard, the incidence, fatality and recurrence rates of cardiovascular disease (CVD) are increasing year by year, which seriously affects people's life and health. Conventional therapeutic drugs have limited improvement on the disability rate, so the search for new therapeutic drugs and action targets has become one of the hotspots of current research. In recent years, the therapeutic role of the natural compound rosmarinic acid (RA) in CVD has attracted much attention, which is capable of preventing CVD by modulating multiple signalling pathways and exerting physiological activities such as antioxidant, anti-apoptotic, anti-inflammatory, anti-platelet aggregation, as well as anti-coagulation and endothelial function protection. In this paper, the role of RA in the prevention of CVD is systematically sorted out, and its mechanism of action is summarised and analysed, with a view to providing a scientific basis and important support for the in-depth exploration of the prevention value of RA in CVD and its further development as a prevention drug.
