The role of histone deacetylase 3 in diabetes and its complications, and the research progress on histone deacetylase 3 inhibitors

VernacularTitle:组蛋白去乙酰化酶3在糖尿病及其并发症中的作用及其抑制剂的研究进展
Author: Jia-yu ZHAI ; Cun-yu FENG ; Xue-feng GAO ; Li-ran LEI ; Lei LEI ; Yi HUAN
Publication Type:Research Article
Keywords: histone deacetylase 3; iabetes; complications of diabetes; insulin resistance; islet β cell
From: Acta Pharmaceutica Sinica 2025;60(1):1-11
CountryChina
Language:Chinese
Abstract: Histone deacetylase 3 (HDAC3) is an epigenetic modification enzyme that plays a crucial role in the development and progression of diabetes and its complications. Studies have reported that increased HDAC3 activity is associated with pancreatic β-cell dysfunction in type 1 diabetes, while in type 2 diabetes, HDAC3 affects insulin resistance and signaling by regulating the metabolism of the liver, adipose tissue, and muscle. Additionally, HDAC3 plays a key role in diabetic complications such as cardiomyopathy, retinopathy, and nephropathy. Selective inhibition of HDAC3 has the potential to improve insulin sensitivity, reduce chronic inflammation, and enhance pancreatic cell function, offering a promising new therapeutic strategy for diabetes and its complications.