The technology of fecal microbiota transplantation and its application progress
10.16438/j.0513-4870.2024-0819
- VernacularTitle:粪菌移植技术及其应用进展
- Author:
Shuo YUAN
;
Yi-fan ZHANG
;
Peng GAO
;
Jun LEI
;
Ying-yuan LU
;
Peng-fei TU
;
Yong JIANG
- Publication Type:Research Article
- Keywords:
gut microbiota;
fecal microbiota transplantation;
operational procedure;
clinical treatment;
application progress
- From:
Acta Pharmaceutica Sinica
2025;60(1):82-95
- CountryChina
- Language:Chinese
-
Abstract:
Fecal microbiota transplantation (FMT) technology originated in China during the Eastern Jin Dynasty and has rapidly developed over the past two decades, becoming a primary method for studying the causal relationship between gut microbiota and the occurrence and progression of diseases. At the same time, the therapeutic effects of FMT in the field of gastrointestinal diseases have gained widespread recognition and are gradually expanding into other disease areas. The FMT procedure is relatively complex, and there is currently no standardized method; its success is influenced by various factors, including the donor, recipient, processing of the fecal material, and the method of implantation. Given the increasingly recognized relationship between gut microbiota and various diseases, FMT has become a research hotspot in both scientific studies and clinical applications, achieving a series of significant advancements. To help researchers better understand this technology, this paper will outline the development history of FMT, summarize common operational methods in research and clinical settings, review its application progress, and look forward to future development directions.
