An alkyne and two phenylpropanoid derivants from Carthamus tinctorius L.
10.16438/j.0513-4870.2024-0734
- VernacularTitle:红花中一个炔类和两个苯丙素衍生物
- Author:
Lin-qing QIAO
;
Ge-ge XIA
;
Ying-jie LI
;
Wen-xuan ZHAO
;
Yan-zhi WANG
- Publication Type:Research Article
- Keywords:
safflower;
compositae;
chemical constituent;
alkyne;
phenylpropanoid derivant;
enzymatic hydrolysis
- From:
Acta Pharmaceutica Sinica
2025;60(1):185-190
- CountryChina
- Language:Chinese
-
Abstract:
The chemical constituents from the n-butanol fraction of ethanol extract of safflower (Carthamus tinctorius L.) were isolated and purified using chromatographic process including MCI Gel CHP-20, ODS, Sephadex LH-20 column chromatography, and semi-preparative HPLC method, and one alkyne and two phenylpropanoid derivants were obtained. Their structures were identified as (5R,E)-tetradecane-12-ene-8,10-diyne-1,5,14-triol (1), (E)-8-O-β-D-glucopyranosyl n-butyl cinnamate (2), and (7S,8S)-7-(4-hydroxy-3-methoxybenzene)-7-butyl-8,9-diol (3) by modern spectroscopy methods (1D NMR, 2D NMR, UV, IR and MS). 1-3 are all new compounds. Compounds 1-3 were screened for their anti-renal fibrosis activities in vitro, and none of them showed obvious effect.
