Advances in oral distant targeted nanodelivery systems
10.16438/j.0513-4870.2024-0480
- VernacularTitle:口服远处靶向纳米递送系统的研究进展
- Author:
Min SUN
1
,
2
;
Chuan-sheng HUANG
1
;
Li-ping WANG
3
;
Xu-li RUAN
3
;
Yun-li ZHAO
1
;
Xin-chun WANG
1
Author Information
1. The First Affiliated Hospital of Shihezi University, Shihezi
2. School of Pharmacy, Shihezi University, Shihezi
3. School of Pharmacy, Shihezi University, Shihezi
- Publication Type:Research Article
- Keywords:
oral drug delivery system;
gastrointestinal tract;
physiological disorder;
oral targeted;
oral nanomedicine
- From:
Acta Pharmaceutica Sinica
2025;60(1):72-81
- CountryChina
- Language:Chinese
-
Abstract:
Due to patient compliance and convenience, oral medication is likely the most common and acceptable method of drug administration. However, traditional dosage forms such as tablets or capsules may lead to low drug bioavailability and poor therapeutic efficiency. Therefore, with advancements in material science and micro/nano manufacturing technology, various carriers have been developed to enhance drug absorption in the gastrointestinal tract. In this context, we initially discuss the key biological factors that hinder drug transport and absorption (including anatomical, physical, and biological factors). Building on this foundation, recent progress in both conventional and innovative oral drug delivery routes aimed at improving drug bioavailability and targeting is reviewed. Finally, we explore future prospects for oral drug delivery systems as well as potential challenges in clinical translation.
