Five new triterpenoid saponins from the kernels of Momordica cochinchinensis
10.16438/j.0513-4870.2024-1013
- VernacularTitle:木鳖子仁中5个新的三萜皂苷类成分
- Author:
Ru DING
1
;
Jia-qi WANG
1
;
Yi-yang LUO
1
;
Yong-long HAN
2
;
Xiao-bo LI
1
;
Meng-yue WANG
1
Author Information
1. School of Pharmaceutical Science, Shanghai Jiao Tong University, Shanghai 200240, China
2. Department of Pharmacy, Shanghai Sixth People's Hospital, Shanghai 200233, China
- Publication Type:Research Article
- Keywords:
italic>Momordica cochinchinensis;
ernel;
triterpenoid saponin;
mubezhiside;
antifungal activity;
italic>Candida
- From:
Acta Pharmaceutica Sinica
2025;60(2):442-448
- CountryChina
- Language:Chinese
-
Abstract:
Five saponins were isolated from the kernels of Momordica cochinchinensis, by macroporous resin, silica gel, ODS column chromatography, and semi preparative HPLC. Based on MS and NMR analysis, combining with alkaline hydrolysis and acid hydrolysis, their structures were identified as: gypsogenin-3-O-{β-D-galactopyranosyl (1→2)-[α-L-rhamnopyranosyl (1→3)]-β-D-glucuropyranonosyl}-28-O-β-D-xylopyranosyl (1→3)-[β-D-xylopyranosyl (1→4)]-α-L-rhamnopyranosyl (1→2)-β-D-fucopyranoside (1), quillaic acid-3-O-{β-D-galactopyranosyl (1→2)-[α-L-rhamnopyranosyl (1→3)]-β-D-glucuropyranonosyl}-28-O-β-D-xylopyranosyl (1→3)-[β-D-xylopyranosyl (1→4)]-α-L-rhamnopyranosyl (1→2)-β-D-fucopyranoside (2), gypsogenin-3-O-β-D-galactopyranosyl (1→2)-[α-L-rhamnopyranosyl (1→3)]-β-D-glucuropyranonoside sodium (3), quillaic acid-3-O-β-D-galactopyranosyl (1→2)-[α-L-rhamnopyranosyl (1→3)]-β-D-glucuropyranonoside sodium (4), 18α-quillaic acid-3-O-β-D-galactopyranosyl (1→2)-[α-L-rhamnopyranosyl (1→3)]-β-D-glucuropyranonoside (5). Compounds 1-5 were new compounds, and named as mubezhisides A, B, C, D, E, respectively. They all could obviously inhibited the growth of Candida albicans, C. parapsilosis, and C. tropicalis.
