Research progress of nano drug delivery system based on metal-polyphenol network for the diagnosis and treatment of inflammatory diseases
10.16438/j.0513-4870.2024-0572
- VernacularTitle:基于金属-多酚网络的纳米递药系统在炎症性疾病诊疗方面的研究进展
- Author:
Meng-jie ZHAO
1
;
Xia-li ZHU
1
;
Yi-jing LI
1
;
Zi-ang WANG
1
;
Yun-long ZHAO
1
;
Gao-jian WEI
1
;
Yu CHEN
1
;
Sheng-nan HUANG
2
,
3
Author Information
1. Pharmacy College, Henan University of Chinese Medicine, Zhengzhou 450046, China
2. Academy of Chinese Medical Sciences, Henan University of Chinese Medicine, Zhengzhou 450046, China
3. Collaborative Innovation Center of Research and Development on the Whole Industry Chain of Yu-Yao, Henan Province, Henan University of Chinese Medicine, Zhengzhou 450046, China
- Publication Type:Research Article
- Keywords:
inflammatory disease;
metal polyphenol network;
nano drug delivery system;
iagnosis;
treatment
- From:
Acta Pharmaceutica Sinica
2025;60(2):323-336
- CountryChina
- Language:Chinese
-
Abstract:
Inflammatory diseases (IDs) are a general term of diseases characterized by chronic inflammation as the primary pathogenetic mechanism, which seriously affect the quality of patient′s life and cause significant social and medical burden. Current drugs for IDs include nonsteroidal anti-inflammatory drugs, corticosteroids, immunomodulators, biologics, and antioxidants, but these drugs may cause gastrointestinal side effects, induce or worsen infections, and cause non-response or intolerance. Given the outstanding performance of metal polyphenol network (MPN) in the fields of drug delivery, biomedical imaging, and catalytic therapy, its application in the diagnosis and treatment of IDs has attracted much attention and significant progress has been made. In this paper, we first provide an overview of the types of IDs and their generating mechanisms, then sort out and summarize the different forms of MPN in recent years, and finally discuss in detail the characteristics of MPN and their latest research progress in the diagnosis and treatment of IDs. This research may provide useful references for scientific research and clinical practice in the related fields.
