Research progress on molecular mechanism of capsular polysaccharide-mediated bacteriophage tolerance regulated by LuxR quorum sensing system in Gram-negative bacteria

VernacularTitle:革兰阴性菌LuxR群体感应系统调控荚膜多糖介导噬菌体耐受分子机制的研究进展
Author: QIU Wenwen
Publication Type:Journal Article
Keywords: Gram-negative bacteria; LuxR quorum sensing system; Capsular polysaccharide(CPS); Bacteriophage; Tolerance
From: Chinese Journal of Biologicals 2025;38(03):379-383
CountryChina
Language:Chinese
Abstract: Capsular polysaccharides(CPSs) are located on the surface of Gram-negative bacterial cells and form a vesicular structure covering the surface, which are receptors for bacteriophages to adsorb host bacteria and determine their lytic activity and host range. The quorum sensing gene luxR inhibits phage adsorption by regulating reduced CPS expression,making Gram-negative bacteria tolerant to phages. LuxR quorum sensing system is a kind of intercellular communication system widely existing in Gram-negative bacteria, which is responsible for synthesizing self-inducers, sensing and responding to N-acyl-homoserine lactones(AHLs) signals, and can regulate biofilm formation, control the production of virulence factors,coordinate group behavior and mediate bacteria-environment interaction, playing a key role in the regulation of bacterial group behavior. This paper reviews the research progress on molecular mechanism of CPS-mediated phage tolerance regulated by LuxR quorum sensing system in Gram-negative bacteria, aiming to provide new ideas for phage therapy for bacterial infection.