Advances of controlled human malaria infection and its application in development of vaccines against Plasmodium falciparum malaria
10.13200/j.cnki.cjb.004443
- VernacularTitle:人体受控疟疾感染试验的研究进展及其在恶性疟原虫疫苗研发中的应用
- Author:
TONG Yue
- Publication Type:Journal Article
- Keywords:
Human challenge trials(HCTs);
Controlled human malaria infection(CHMI);
Malaria vaccine;
Plasmodium falciparum
- From:
Chinese Journal of Biologicals
2025;38(03):366-372
- CountryChina
- Language:Chinese
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Abstract:
Malaria is one of the most common insect-borne infectious diseases in the world. Among the five known malaria parasites infecting human beings, Plasmodium falciparum has the highest morbidity and mortality, and is one of the most important public health problems in the epidemic areas. With the increasing drug resistance of malaria parasites, people′s demand for malaria vaccine is more urgent. Human challenge trials(HCTs) can obtain preliminary evidence of vaccine effectiveness and safety by vaccinating fewer subjects, which is faster than traditional clinical trials, being a feasible method to study pathogenesis, immune mechanism and evaluate the efficacy of vaccine candidates. As a kind of HCTs against malaria,controlled human malaria infection(CHMI) has been widely used in clinical trials of malaria vaccines. In this paper, the application of HCTs in malaria research, the materials and methods of establishing CHMI model of Plasmodium falciparum,and the application of CHMI in malaria vaccine development were reviewed in order to provide new ideas for accelerating the development and improvement of new malaria vaccines.
