Correlation analysis of incidence trend and vaccination of HFMD before and after EV71 vaccination in Shijingshan District, Beijing
10.13200/j.cnki.cjb.004438
- VernacularTitle:北京市石景山区肠道病毒71型疫苗接种前后手足口病发病趋势与接种相关性分析
- Author:
SHI Manli
- Publication Type:Journal Article
- Keywords:
Hand-foot-mouth disease(HFMD);
Enterovirus 71(EV71) inactivated vaccine;
Incidence trend
- From:
Chinese Journal of Biologicals
2025;38(03):318-322+329
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the correlation between the incidence trend and vaccination of hand-foot-mouth disease(HFMD) before and after enterovirus 71(EV71) vaccination in Shijingshan District,Beijing,and to provide a reference for the prevention and control strategies of HFMD.Methods The incidence data of HFMD in children aged 6 months to 12 years before and after EV71 vaccination were collected from the National Disease Prevention and Control Information System from2011 to 2022 and the vaccination data of EV71 inactivated vaccine in Shijingshan District,Beijing from 2017 to 2022 were collected from the Beijing Children Immunization Program Information System,aiming to analyze the variation trend of the incidence rate of HFMD and the detection rate of EV71 in children aged 6 months to 12 years before and after EV71 vaccination with years.The correlation between the cumulative EV71 vaccine vaccination rate and the incidence rate of HFMD as well as the detection rate of EV71 was analyzed by Spearman categorical variable correlation analysis and trend χ~2 test.Results In Shijingshan District,the incidence of HFMD in children aged 6 months to 12 years ranged from 71.32 to 2 447.7/100 000,and the incidence trend was that the incidence intensity of HFMD decreased significantly after EV71 vaccination.The proportion of severe cases gradually decreased to zero,the severe cases and EV71 infection decreased obviously,and the protective effect was better on nursery children than scattered children.However,it was not considered that the EV71 detection rate and incidence of HFMD in children aged 6 months to 12 years were negatively correlated with EV71 vaccination.(r_s=-0.771 and-0.638,P=0.072 and 0.173,respectively) Conclusion EV71 vaccination can effectively prevent and control the epidemic of HFMD,especially the epidemic caused by EV71 infection.
