Advances in metabolic mechanism of innate immune response against SARS-CoV-2
10.13200/j.cnki.cjb.004417
- VernacularTitle:抗SARS-CoV-2天然免疫反应代谢机制的研究进展
- Author:
HAO Bingbing
- Publication Type:Journal Article
- Keywords:
SARS-CoV-2;
Glycolysis;
Macrophages
- From:
Chinese Journal of Biologicals
2025;28(02):242-247
- CountryChina
- Language:Chinese
-
Abstract:
COVID-19 caused by SARS-CoV-2 infection poses a great threat to the lives of people around the world and has become a major global public health challenge. The innate immune system is the body's first line of defense against viral invasion and plays an important role in the development of COVID-19. As the main immune cells in the innate immune system, monocyte macrophages have pattern recognition receptors on their surface that recognize SARS-CoV-2 singlestranded RNA and damage associated molecular patterns(DAMPs) and induce antiviral innate immune responses. However,SARS-CoV-2 has a strong immune escape ability and can rapidly expand and replicate in host cells and induce host cell death, which further induces an inflammatory response and exacerbates COVID-19. Studies have shown that macrophage infiltration-induced hyperinflammatory responses(i.e., cytokine storms) are an important lethal mechanism of COVID-19,and that during SARS-CoV-2 infection, the over-activation of glycolysis is an important metabolic mechanism for viral immune escape and inflammatory response. This paper reviews the related research progress of glucose metabolism in the innate immune response against SARS-CoV-2.
