Research progress on rodent models infected by SARS-CoV-2 variant strains
10.13200/j.cnki.cjb.004415
- VernacularTitle:SARS-CoV-2变异株感染啮齿类动物模型的研究进展
- Author:
WANG Ruyu
- Publication Type:Journal Article
- Keywords:
SARS-CoV-2;
Variants;
Rodents;
Infection model
- From:
Chinese Journal of Biologicals
2025;28(02):215-220
- CountryChina
- Language:Chinese
-
Abstract:
The infection caused by SARS-CoV-2 is a very widespread epidemic disease. Rodent models have played an important role in studying the pathogenesis and immune response of SARS-CoV-2 infection, as well as in developing drugs or vaccines for treatment and prevention. However, the accumulation of SARS-CoV-2 mutations and their rapid spread in the population have led to the emergence of mutant strains that evade host immune responses. The current SARS-CoV-2 vaccine may not be able to effectively control the spread of mutant strains, so the research and development of vaccines and drugs for the prevention and treatment of mutant strains will continue. Rodents are crucial to the study of virus etiology, transmission and pathogenesis, and have played an important role in the early development of related inactivated vaccines and antibodies.This review mainly summarizes the research progress of rodent models in SARS-CoV-2 Alpha, Beta, Gamma, Delta, Omicron mutants.
