Advances in VapBC family of Mycobacterium tuberculosis type Ⅱ toxin-antitoxin system
10.13200/j.cnki.cjb.004407
- VernacularTitle:结核分枝杆菌Ⅱ型毒素-抗毒素系统VapBC家族的研究进展
- Author:
FU Bo
- Publication Type:Journal Article
- Keywords:
Mycobacterium tuberculosis(Mtb);
Toxin-antitoxin(TA) system;
VapBC family;
Stress response;
Protein structure
- From:
Chinese Journal of Biologicals
2025;38(1):115-121
- CountryChina
- Language:Chinese
-
Abstract:
There are many type Ⅱ toxin-antitoxin(TA) systems in Mycobacterium tuberculosis(Mtb), among which the VapBC family is the most abundant TA system including toxin VapCs and antitoxin VapB. Toxin VapCs are usually ribonucleases(RNases) with a PilT N-terminal(PIN) domain that can cleave tRNA or sarcin-ricin loop(SRL) of 23S rRNA to exert the toxicity. Antitoxin VapB regulates the expression level of homologous toxins by binding to promoter DNA or directly binds to homologous toxins to inhibit their toxicity. The VapBC family is closely associated with the growth, pathogenicity and drug resistance of Mtb. Therefore, the function of Mtb VapBC family, substrate specificity of toxin VapCs, structures of VapBC,and structure-based drug development were summarized in this paper, in view to providing new ideas for the treatment of tuberculosis(TB).
