Application of liquid chromatography and mass spectrometry in vaccine quality control
10.13200/j.cnki.cjb.004014
- VernacularTitle:液相色谱和质谱技术在疫苗质控中的应用
- Author:
WU Yan
- Publication Type:Journal Article
- Keywords:
Liquid chromatography(LC);
Mass spectrometry;
Liquid chromatography tandem mass spectrometry;
Quality control
- From:
Chinese Journal of Biologicals
2025;38(1):109-114
- CountryChina
- Language:Chinese
-
Abstract:
High separation efficiency and fast separation speed of liquid chromatography(LC), strong sensitivity and good selectivity of mass spectrometry technology, have realized the wide use of LC and mass spectrometry technology in the field of biological macromolecules. In recent years, LC and mass spectrometry technology are gradually becoming universal in the field of vaccines, and play an increasingly important role in the quality control of vaccines. This paper summarized the application of LC and mass spectrometry technology in inactivated vaccines, vaccines of virus-like particles(VLPs), polysaccharide vaccines, and polysaccharide conjugate vaccines.
