Traditional Chinese medicine regulates the gut microbiota-bile acids-FXR axis to intervene in the development of colorectal cancer
10.16438/j.0513-4870.2024-0568
- VernacularTitle:肠道菌群-胆汁酸-FXR轴干预结直肠癌的研究进展及中药干预的现状分析
- Author:
Ya-ni WANG
1
,
2
;
Xiao-yu ZHANG
1
,
2
;
Yu-ping LIU
1
,
2
,
3
;
Xiao-ying QIN
1
,
2
;
Jie-ge HUO
1
,
3
;
Yan CHEN
1
,
2
,
3
;
Huang-qin ZHANG
1
,
4
Author Information
1. Affiliated Hospital of Integrated Traditional Chinese Medicine, Nanjing University of Chinese Medicine, Nanjing
2. Multi-component of Traditional Chinese Medicine and Microecology Research Center, Jiangsu Provincial Academy of Chinese Medicine, Nanjing
3. Jiangsu Clinical Innovation Center for Traditional Chinese Medicine, Nanjing
4. State Key Laboratory on Technologies for Chinese Medicine Pharmaceutical Process Control and Intelligent Manufacture, Nanjing University of Chinese Medicine, Nanjing
- Publication Type:Research Article
- Keywords:
colorectal cancer;
intestinal microbiota;
traditional Chinese medicine;
bile acid;
farnesoid X receptor
- From:
Acta Pharmaceutica Sinica
2024;59(11):3027-3041
- CountryChina
- Language:Chinese
-
Abstract:
The gut microbiota plays a crucial role in the development of colorectal cancer (CRC). The imbalanced gut microbiota causes damage to the body and disrupts bile acids metabolism, increases susceptibility to CRC, and affects the signaling of farnesol X receptor (FXR), thereby promoting CRC progression. Traditional Chinese medicine has unique advantages in the treatment of CRC due to its synergistic regulatory effects of multiple components, targets, and pathways. It can regulate gut microbiota, intervene in bile acids metabolism, and activate its receptor FXR to inhibit the occurrence and development of CRC. Based on this, this article discusses the main role of the gut microbiota-bile acids-FXR axis in the development of CRC, and reviews the anti CRC effects and mechanisms of traditional Chinese medicine intervention on gut microbiota-bile acids-FXR axis, in order to provide new ideas and methods for the prevention and treatment of CRC.
