Current status and perspectives of small molecule inhibitors of heat shock protein 70
10.16438/j.0513-4870.2024-0462
- VernacularTitle:热休克蛋白70小分子抑制剂的研究进展
- Author:
Jin-yan ZHU
;
Ming-hui HE
;
Fan WU
;
Ying-lan YU
;
Lei LUO
;
Hao SHAO
- Publication Type:Research Article
- Keywords:
heat shock protein 70;
molecular chaperone;
small molecule inhibitor;
allosteric inhibitor;
protein-protein interaction
- From:
Acta Pharmaceutica Sinica
2024;59(11):2962-2974
- CountryChina
- Language:Chinese
-
Abstract:
Heat shock protein 70 (Hsp70) is a class of molecular chaperones essential for maintaining protein homeostasis in cells. Hsp70s also play important roles in the pathogenesis of a variety of diseases, including cancer, neurodegenerative diseases and infectious diseases, which makes them potential targets for the treatment of these diseases. It is necessary to develop small molecule inhibitors to validate this class of important therapeutic targets. In recent years, the discovery of small molecule inhibitors for Hsp70s has made remarkable progress, and Hsp70 inhibitors with different modalities have been reported. In this paper, Hsp70 and relevant diseases are briefly introduced, and the discovery of Hsp70 small molecule inhibitors with distinct modalities are summarized, providing reference for the further discovery and development of Hsp70 small molecule inhibitors.
