Phenolic acid compounds from Phellodendron chinense and their activity on α-glucosidase inhibition
10.16438/j.0513-4870.2024-0329
- VernacularTitle:黄皮树中的酚酸类化合物及抑制α-葡萄糖苷酶活性
- Author:
Yu-lin ZHANG
;
Si-qi LI
;
Lan-zhu ZHU
;
Xuan-qin CHEN
- Publication Type:Research Article
- Keywords:
italic>Phellodendronchinense;
non-alkaloid;
phenolic acid;
isophellolactone;
italic>α-glucosidase inhibitory activity
- From:
Acta Pharmaceutica Sinica
2024;59(11):3130-3134
- CountryChina
- Language:Chinese
-
Abstract:
The non-alkaloid chemical constituents of dried Phellodendron chinense barks were investigated. A total of 14 phenolic compounds (1-14) were isolated from the 95% ethanol extract of Phellodendron chinense by the utilization of silica gel, medium pressure liquid chromatography, Sephadex LH-20 column chromatography, and preparative liquid chromatography. Among of the isolated compounds, isophellolactone (1) was identified as a new compound. The isolated 14 compounds were further tested the activity on α-glucosidase inhibition. The results for the first time demonstrated that quininic acid ester 3-6 and 8 exhibited good α-glucosidase inhibitory activity. Polyhydroxy hexa-membered carbon ring in quinine ester derivatives is possibly the essential group for the α-glucosidase inhibitory activity.
