Research progress on mRNA pulmonary delivery systems
10.16438/j.0513-4870.2024-0139
- VernacularTitle:mRNA肺部递送系统研究进展
- Author:
Ze-hong CHEN
1
,
2
,
3
,
4
;
Xin-yu ZHANG
5
;
Hao-nan XING
6
;
Mei LU
7
;
Fan MENG
6
;
Jing-ru LI
6
;
Xiu-li GAO
1
,
2
;
Ai-ping ZHENG
6
Author Information
1. State Key Laboratory of Functions and Applications of Medicinal Plants &
2. School of Pharmaceutical Sciences, Guizhou Medical University, Guiyang
3. State Key Laboratory of National Security Specially Needed Medicines, Academy of Military Medical Sciences, Beijing
4. Microbiology and Biochemical Pharmaceutical Engineering Research Center of Guizhou Provincial Department of Education, Guizhou Medical University, Guiyang
5. Xinjiang Medical University, Urumqi
6. State Key Laboratory of National Security Specially Needed Medicines, Academy of Military Medical Sciences, Beijing
7. Advanced Research Institute of Multidisciplinary Science, Beijing Institute of Technology, Beijing
- Publication Type:Research Article
- Keywords:
mRNA;
inhalation preparation;
pulmonary delivery;
pulmonary barrier;
nano delivery system;
vaccine
- From:
Acta Pharmaceutica Sinica
2024;59(11):3074-3084
- CountryChina
- Language:Chinese
-
Abstract:
As a major global public health problem, pulmonary diseases threaten human life and health while causing a huge economic burden. The messenger RNA (mRNA)-based inhalation preparation, which effectively targets pulmonary cells can overcome the problems of traditional therapy, such as high side effects, low pulmonary bioavailability, and difficulty in synthesizing target proteins in vitro, thus providing new ideas for the treatment of pulmonary diseases. However, as the lung structure is complex and mRNA has trouble entering cells, researchers have been attempting to develop a suitable nano delivery system for higher delivery efficiency. This review introduces the barriers to pulmonary delivery, discusses the recent research development of the mRNA pulmonary delivery systems, including lipid nanoparticles, polymeric nanoparticles, polypeptides and exosomes, summarizes their limitations and looks forward to the application of mRNA inhalation preparations.
