A new alkaloid from Huperzia serrata and its biological activity
10.16438/j.0513-4870.2024-0843
- VernacularTitle:千层塔中一个新的生物碱及其生物活性研究
- Author:
Xiao-ting QIAO
1
,
2
;
Xin-xin CHENG
1
;
Dan WANG
1
;
Mei-han LAI
3
;
Jia-qi WANG
3
;
Xiao-min WANG
1
,
2
;
Cai-lian RUAN
3
;
Duo CAO
1
Author Information
1. Shaanxi Key Laboratory of Research and Utilization of Resource Plants on the Loess Plateau, Shaanxi Engineering and Technological Research Center for Conversation and Utilization of Regional Biological Resources, College of Life Sciences, Yan'an University, Yan'an
2. Medical School of Yan'an University, Yan'an
3. Medical School of Yan'an University, Yan'an
- Publication Type:Research Article
- Keywords:
italic>Huperzia serrata;
chemical composition;
alkaloid;
structural identification;
antioxidant
- From:
Acta Pharmaceutica Sinica
2024;59(12):3342-3346
- CountryChina
- Language:Chinese
-
Abstract:
The methanol extract of Huperzia serrata was separated and purified by ODS, AB-8 macroporous adsorption resin, dextran gel Sephadex LH-20 and silica gel column chromatography combined with the semi-pre HPLC. The chemical structures of the isolated compounds were identified by MS, IR, NMR, etc. Four compounds were isolated from Huperzia serrata and identified, named as serratinine C (1), lycobeline C (2), diphaladin A (3) and crenatine (4). Compound 1 is a new alkaloid, compounds 2-4 were isolated for the first time. In vitro biological activity experiments showed that compound 1 could significantly reduce the levels of nitric oxide and reactive oxygen species in glial cells induced by lipopolysaccharide and had significant antioxidant biological activity.
