Study on improving the photostability of nifedipine by crystal engineering
10.16438/j.0513-4870.2024-0701
- VernacularTitle:晶体工程改善硝苯地平光稳定性研究
- Author:
Xin MENG
;
Yao ZOU
;
Mei-ju LIU
;
Cheng XING
;
Ning-bo GONG
;
Yang LÜ
- Publication Type:Research Article
- Keywords:
crystal engineering;
nifedipine;
cocrystal;
characterization;
photostability
- From:
Acta Pharmaceutica Sinica
2024;59(12):3374-3378
- CountryChina
- Language:Chinese
-
Abstract:
In order to improve the poor photostability of nifedipine, this study designed a cocrystal based on the principles of crystal engineering and prepared nifedipine-imidazole cocrystal by suspension method. The new cocrystal was characterized by powder X-ray diffraction (PXRD), differential scanning calorimetry (DSC), thermogravimetric analysis (TG) and infrared spectroscopy (IR) to confirm the formation of the cocrystal. The photostability of nifedipine and its cocrystal was measured by powder X-ray diffraction and high-performance liquid chromatography (HPLC). The results showed that the nifedipine-imidazole cocrystal improved the photostability of nifedipine to a certain extent. This study provides guidance for the development of nifedipine cocrystals and the improvement of its druggability.
