Research progress of nuclear bodies in tumor
10.16438/j.0513-4870.2024-0597
- VernacularTitle:核体在肿瘤中的研究进展
- Author:
Qing-yuan LIU
;
Yun-yao LIU
;
Yi-ting XU
;
Yu-jiao XU
;
Lei QIANG
- Publication Type:Research Article
- Keywords:
nuclear body;
nucleolus;
promyelocytic leukemia nuclear body;
nuclear speckle;
paraspeckle;
tumor
- From:
Acta Pharmaceutica Sinica
2024;59(12):3179-3188
- CountryChina
- Language:Chinese
-
Abstract:
The mammalian cell nucleus is highly structured and organized into various membrane-less nuclear compartments called nuclear bodies. Nuclear bodies are highly dynamic structures, with a variety of substances gathered inside to promote the more efficient conduct of certain biological reactions. It dynamically produces responses under different biological processes and stress conditions such as tumorigenesis, apoptosis, antiviral defense, and plays an important role in regulating cell homeostasis. Tumor is a major public health problem, and finding new targets is the key to tumor therapy. How the nuclear bodies are involved in the development of tumor has not been reported. This review aims to provide a new understanding of how the nuclear bodies regulates tumor progression and provide a new effective strategy for tumor prevention and treatment.
