METTL3 mediates m6A modification in ocular diseases
10.3980/j.issn.1672-5123.2025.4.17
- VernacularTitle:METTL3介导m6A修饰在眼科疾病中的作用
- Author:
Canyu WANG
1
,
2
;
Ruiyu YANG
1
,
2
;
Xuan LIAO
1
,
2
Author Information
1. Department of Ophthalmology, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, Sichuan Province, China
2. Medical School of Ophthalmology & Optometry, North Sichuan Medical College, Nanchong 637000, Sichuan Province, China
- Publication Type:Journal Article
- Keywords:
methyltransferase-like 3(METTL3);
m6A RNA methylation;
N6-methyladenosine(m6A);
ocular disease;
pathogenesis
- From:
International Eye Science
2025;25(4):615-619
- CountryChina
- Language:Chinese
-
Abstract:
N6-methyladenosine(m6A)is recognized as the most prevalent mRNA modification in mammals, intricately involved in a multitude of processes pertaining to mRNA metabolism, encompassing RNA transcription, translation, and degradation. It plays a pivotal role in various physiological functions. Under the coordinated actions of methyltransferases, demethylases, and m6A-binding proteins, m6A modifications undergo reversible changes to fulfill their diverse molecular functions.Methyltransferase-like 3(METTL3), as the core catalytic subunit of methyltransferases and the most extensively studied methyltransferase, holds a central position in m6A modification. In recent years, it has been found that METTL3-mediated m6A modification is involved in the occurrence and development of various ocular diseases, such as ocular surface diseases, glaucoma, cataract, retinal diseases, and ocular tumors, by affecting the expression of inflammatory factors and thus regulating the inflammatory response, and by regulating various pathways that affect the proliferation of cells and oxidative stress. In this paper, we comprehensively review the mechanisms under the role of METTL3 in ocular diseases, offering novel insights and perspectives for the prevention and management of these conditions.
