Advances in minimally invasive glaucoma surgeries for open-angle glaucoma based on the trabecular meshwork-Schlemm's canal pathway
10.3980/j.issn.1672-5123.2025.4.11
- VernacularTitle:基于小梁网-Schlemm管途径的微创青光眼手术治疗开角型青光眼的研究进展
- Author:
Sukun MENG
1
,
2
,
3
;
Jianrong LIU
1
,
2
,
3
Author Information
1. Xi'an People's Hospital(Xi'an Fourth Hospital)
2. Shaanxi Eye Hospital
3. Affiliated People's Hospital of Northwest University, Xi'an 710004, Shaanxi Province, China
- Publication Type:Journal Article
- Keywords:
minimally invasive glaucoma surgeries;
trabecular meshwork;
aqueous humor outflow pathway;
open-angle glaucoma
- From:
International Eye Science
2025;25(4):583-588
- CountryChina
- Language:Chinese
-
Abstract:
Glaucoma is the leading cause of irreversible blindness worldwide. Reducing intraocular pressure through surgical interventions is a crucial approach for managing open-angle glaucoma(OAG). In recent years, minimally invasive glaucoma surgeries(MIGS)have gained prominence, providing a lot of options for the treatment of glaucoma. MIGS that target the trabecular meshwork-Schlemm's canal pathway act on the main pathway of aqueous humor outflow with less damage to the normal anatomical structures of the eye, and are gradually becoming the mainstream procedures. These surgeries can be categorized into three main types based on their mechanisms of action: trabeculotomy, trabecular meshwork bypass, and Schlemm's canal dilation. Representative procedures and devices include gonioscopy-assisted transluminal trabeculotomy(GATT), microcatheter-assisted trabeculotomy(MAT), Trabectome, kahook dual blade(KDB), tanito microhook(TMH), excimer laser trabeculotomy(ELT), iStent series, Hydrus, ABiC, PCP and 3T procedures. This article reviews the current literature on the application of MIGS targeting the trabecular meshwork-Schlemm's canal pathway in OAG. It aims to discuss the principles, efficacy and safety of such MIGS for the treatment of OAG, and to summarize the advantages and disadvantages of each procedure, with a view to informing the choice of surgical treatment and clinical research for OAG.
