Research status and prospect of prevention and treatment of radiation-induced lung injury
10.13491/j.issn.1004-714X.2025.01.022
- VernacularTitle:放射性肺损伤防治研究现状与展望
- Author:
Bo ZHENG
1
,
2
;
Guirong DING
1
,
2
Author Information
1. Department of Radiation Medical Protection, School of Military Preventive Medicine, Fourth Military Medical University, Shaanxi Province, Xi'an 710032 China
2. Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational Environment, Shaanxi Province, Xi'an 710032 China.
- Publication Type:ReviewArticles
- Keywords:
Radiation-induced lung injury;
Pathogenesis;
Prevention and treatment;
Mesenchymal stem cell
- From:
Chinese Journal of Radiological Health
2025;34(1):135-141
- CountryChina
- Language:Chinese
-
Abstract:
Radiotherapy is a primary modality for thoracic malignant tumor treatment; however, it can also induce damage to normal lung tissue. The pathogenesis of radiation-induced lung injury remains unclear and is believed to be primarily associated with DNA damage and inflammatory responses. The existing drugs for the prevention and treatment of radiation-induced lung injury are limited by issues such as modest efficacy, short half-life, and serious adverse reactions. It is urgent to find new effective prevention and treatment methods. Recently, stem cell-based therapies and traditional Chinese medicine have emerged as promising treatment strategies, offering new hope for patients with radiation-induced lung injury. This review outlines the fundamental aspects of radiation-induced lung injury and discusses potential strategies for its prevention and treatment.
