Associations of multi-slice helical CT features and EGFR/IGF1R expression levels with the pathological types of adrenal cortical tumors
10.13491/j.issn.1004-714X.2025.01.017
- VernacularTitle:多层螺旋CT特征及EGFR、IGF1R表达水平与肾上腺 皮质肿瘤病理类型的相关性
- Author:
Qi LI
1
;
Lili YANG
2
;
Yunjing ZHANG
1
Author Information
1. The First Ward, Department of Nephropathy, Zibo Municipal Central Hospital, Zibo 255000 China.
2. Department of Clinical Pharmacy, Zibo Municipal Central Hospital, Zibo 255000 China.
- Publication Type:OriginalArticles
- Keywords:
Multi-slice spiral CT;
Adrenal cortical tumor;
Epidermal growth factor receptor;
Insulin-like growth factor 1 receptor
- From:
Chinese Journal of Radiological Health
2025;34(1):102-107
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the value of multi-slice spiral computed tomography (MSCT) features, along with the expression levels of epidermal growth factor receptor (EGFR) and insulin-like growth factor 1 receptor (IGF1R), in differential diagnosis of benign and malignant adrenal cortical tumors. Methods A total of 98 patients with adrenal cortical tumors admitted to Zibo Municipal Central Hospital from January 2020 to July 2024 were included in this study. All subjects underwent MSCT scans of the adrenal gland. The CT values of tumor parenchyma on plain scans and at arterial and venous phases were estimated. The surgical tumor specimens were collected for immunohistochemical staining and measurement of EGFR and IGF1R expression. The MSCT features and EGFR and IGF1R expression levels were compared among patients with different pathological types of adrenal cortical tumors. Results Of the 98 patients with adrenal cortical tumors, there were 18 cases with cortical carcinoma, 10 cases with metastatic tumors, 31 cases with pheochromocytoma, 25 cases with aldosterone-producing adenomas, and 14 cases with cortisol adenomas. The CT values of adrenal aldosterone-producing adenomas were significantly lower than other pathological types of adrenal cortical tumors on plain scans and at arterial and venous phases (P < 0.05). The CT values of metastatic tumors and cortical carcinoma were significantly lower than those of pheochromocytoma and cortisol adenomas at arterial and venous phases (P < 0.05). Specifically, at arterial and venous phases, the CT values of metastatic tumors were lower than those of cortical carcinoma, and the CT values of cortisol adenomas were lower than those of pheochromocytoma (P < 0.05). The positive expression levels of EGFR and IGF1R were higher in tumor specimens from patients with metastatic tumors and cortical carcinomas than from pheochromocytoma, aldosterone-producing adenomas, and cortisol adenomas (P < 0.05). There were no significant differences between patients with metastatic tumors and cortical carcinomas in terms of positive EGFR and IGF1R expression (P > 0.05). In addition, there were no significant differences in the proportions of positive EGFR and IGF1R expression among patients with malignant adrenal cortical tumors in terms of ages, genders, tumor sizes, and TNM stages (P > 0.05). Conclusion The CT values of MSCT scans at arterial and venous phases as well as EGFR and IGF1R expression levels correlate with the pathological types of adrenal cortical tumors.
