Association Between the Coexistence of Chronic Non-communicable Diseases and Quality of Life in Middle-aged and Elderly People Living with HIV/AIDS
10.13471/j.cnki.j.sun.yat-sen.univ（med.sci）.2025.0119
- VernacularTitle:中老年HIV/AIDS患者合并慢性非传染性疾病情况与生命质量的关联研究
- Author:
Yao ZHANG
1
;
Chi ZHANG
2
;
Cong LIU
3
;
Haidan ZHONG
3
;
Peishan DU
3
;
Quanmin LI
3
;
Linghua LI
3
;
Jing GU
1
Author Information
1. School of Public Health， Sun Yat-sen University， Guangzhou 510080， China
2. Hospital-Acquired Infection Control Department， Guangzhou Eighth People’s Hospital， Guangzhou Medical University， Guangzhou 510440， China
3. Infectious Disease Center， Guangzhou Eighth People’s Hospital， Guangzhou Medical University， Guangzhou 510440， China
- Publication Type:Journal Article
- Keywords:
HIV;
AIDS;
middle-aged and elderly;
chronic non-communicable diseases;
prevalence;
quality of life
- From:
Journal of Sun Yat-sen University(Medical Sciences)
2025;46(1):161-171
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo investigate the prevalence rate of chronic non-communicable diseases （NCDs） and the association with quality of life in middle-aged and elderly patients with HIV/AIDS. MethodsThis cross-sectional study surveyed 432 patients with HIV/AIDS （aged≥45 years） in the Infectious Disease Center in Guangzhou Eighth People’s Hospital of Guangzhou Medical University， and 366 participants were included in the analysis after quality control. A questionnaire and the EuroQol 5-Dimensional 3-level version （EQ-5D-3L） were used to investigate NCDs and quality of life and Tobit regression model was used to estimate the association between chronic diseases and quality of life. ResultsAmong the 366 participants， 29（7.9%） had cardiovascular disease， 45（12.3%） had hypertension， 122（33.3%） had hyperglycemia， 151（41.3%）had hyperlipidemia，7（1.9%） had cancer， 17 （4.6%） had chronic kidney disease， 38 （10.4%） had chronic liver disease， 21（5.7%） had musculoskeletal disorders， and 253（69.1%） suffered from at least one type of chronic diseases. The median （lower and upper quartiles） of EQ-5D utility index was 1.000（0.964~1.000）. Multivariate Tobit regression results of the total population showed that cancer ［ba=-0.08，95%CI （-0.15，-0.01），P=0.036］， chronic kidney disease ［ba=-0.07， 95%CI （-0.12，-0.02），P=0.006］， musculoskeletal disease ［ba=-0.09， 95%CI （-0.13， -0.05），P<0.001］， and ≥3 types of chronic diseases［ba=-0.05， 95%CI（-0.08，-0.01），P=0.013］ were negatively correlated with EQ-5D utility index. The stratified analysis results of different CD4+T cell levels showed that hypertension ［ba=-0.07， 95%CI （-0.12， -0.02）， P=0.007］， chronic kidney disease ［ba=-0.10，95%CI （-0.18，-0.03）， P=0.006］， musculoskeletal disease ［ba=-0.15， 95%CI （-0.22，-0.07）， P<0.001］ and ≥3 types of chronic diseases ［ba=-0.09， 95%CI （-0.09， -0.01）， P<0.001］ were negatively correlated with EQ-5D utility index in the group with CD4≤500 （cells/μL）， whereas cancer［ba=-0.11， 95%CI （-0.20，-0.01）， P=0.031］ was negatively correlated with EQ-5D utility index in the group with CD4＞500（cells/μL）. ConclusionsThe prevalence rate of chronic non-communicable diseases in middle-aged and elderly patients with HIV/AIDS is relatively high. The classification of NCDs such as cancer or chronic kidney disease or other chronic diseases and the numbers of NCDs categories are negatively correlated with quality of life. However，this association varies among patients with HIV/AIDS of different CD4+T cell levels. It is suggested that we should try to prevent and identify NCDs at an early stage， strengthen linkages and integration of health services for AIDS and chronic NCDs， and jointly manage and control AIDS with chronic diseases to improve the quality of life among people living with HIV/AIDS.
