Traditional Chinese Medicine Intervention in Diarrhea-predominant Irritable Bowel Syndrome Based on Gut-brain Axis： A Review
10.13422/j.cnki.syfjx.20241718
- VernacularTitle:基于“肠-脑轴”探讨中医药干预腹泻型肠易激综合征的研究进展
- Author:
Jinchan PENG
1
;
Jinxiu WEI
2
;
Zhu LIU
1
;
Lijian LIU
2
;
Liqun LI
2
;
Chengning YANG
2
;
Guangwen CHEN
2
;
Jianfeng LI
2
;
Sheng XIE
2
Author Information
1. Graduate School of Guangxi University of Chinese Medicine， Nanning 530001， China
2. The First Affiliated Hospital of Guangxi University of Chinese Medicine， Nanning 530001， China
- Publication Type:Journal Article
- Keywords:
diarrhea-predominant irritable bowel syndrome;
gut-brain axis;
traditional Chinese medicine;
research progress
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2025;31(8):311-319
- CountryChina
- Language:Chinese
-
Abstract:
Diarrhea-predominant irritable bowel syndrome （IBS-D） is a common digestive system disease with high prevalence and recurrence rates for years， high treatment costs， and serious impacts on patients' quality of life and economic burden. Therefore， it is important to explore new and safe treatment methods. The pathogenesis of IBS-D is complex， in which the gut-brain axis is a key factor. The gut-brain axis， a bidirectional signaling pathway connecting the gastrointestinal tract and the central nervous system， regulates gastrointestinal motility， secretion， and immune responses， playing a key role in the occurrence and development of IBS-D. Up to now， antidiarrheal agents， probiotics， and neurotransmitter modulators are the main methods for the clinical treatment of IBS-D. Although they can partially curb the progression of this disease， the therapeutic effects remain to be improved. Studies have confirmed that traditional Chinese medicine （TCM） has significant advantages in the treatment of IBS-D since it can regulate the gut-brain axis via multiple pathways and targets to improve the gastrointestinal motility and strengthen immune defenses. However， there is a lack of systematic reviews on the regulation of the gut-brain axis by TCM in the treatment of IBS-D. Based on the review of IBS-D-related articles published in recent years， this paper systematically summarized the relationship between the gut-brain axis and IBS-D and the role of TCM in the treatment， providing new ideas for the treatment of IBS-D.
