TCM Research of Theories and Prescriptions on Blood Glucose Fluctuation in Diabetes Mellitus： A Review
10.13422/j.cnki.syfjx.20242424
- VernacularTitle:糖尿病血糖波动的中医理论和方剂研究进展
- Author:
Yongjiang ZHU
1
;
Xiaoxu FU
1
;
Hongyan XIE
2
;
Chunguang XIE
2
Author Information
1. Chengdu University of Traditional Chinese Medicine（TCM）， Chengdu 610072， China
2. Hospital of Chengdu University of TCM， Chengdu 610072， China
- Publication Type:Journal Article
- Keywords:
blood glucose fluctuation;
pathogenesis;
prescriptions;
research progress;
review
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2025;31(8):303-310
- CountryChina
- Language:Chinese
-
Abstract:
A systematic review of the traditional Chinese medicine （TCM） literatures published over the past decade on blood glucose fluctuations in diabetes mellitus was conducted to summarize related TCM research progress of theories and prescriptions， so as to provide references for future TCM theoretical exploration， basic research， and clinical prevention and treatment. Blood glucose fluctuation is an independent risk factor for chronic complications of diabetes mellitus， with significant progress made in TCM theories and prescription studies targeting this condition. The TCM theories include "spleen-pancreas homology"， "liver controlling dispersion"， "small intestine transforming qi and separating purity from turbidity"， "Yi Qi Zhou Liu theory"， "Xuan Fu Qi Ye theory"， "Yin-fire theory" and so on， all of which emphasize "Qi". Prescription studies primarily utilize clinical trials， which evaluate plentiful indexes of blood glucose fluctuation such as the mean amplitude of glycemic excursion. Classical and self-formulated prescriptions are widely used， with various dosage forms such as decoctions， granules and capsules. "Qi-Yin deficiency" is the main syndrome of blood glucose fluctuation. Basic research focuses on mechanisms that improve blood glucose fluctuation and reduce chronic complications， such as the renin-angiotensin system regulating islet β cell's function， and the transforming growth factor-β1 inhibiting organ fibrosis. However， there are still some deficiencies in the evidential support and syndrome study of TCM theories， in the high-level evidence-based evaluation， efficacy comparison among multiple dosage forms， and the integration of TCM theories with prescription's clinical research， in the quantities， multi-level verifications， blood glucose fluctuation model establishment and intervention criteria as well as prescription-syndrome correspondence of prescription's basic research， and in the collaboration between clinical and basic research. Despite these challenges， TCM offers a promising approach to improving blood glucose fluctuation and reducing chronic complications in diabetes mellitus， with its rich theories， diverse methods， and proven efficacy.
