Relationship Between Severe Pneumonia and Signaling Pathways and Regulation by Chinese Medicine： A Review
10.13422/j.cnki.syfjx.20241637
- VernacularTitle:重症肺炎与信号通路的关系及中药调控进展
- Author:
Cheng LUO
1
;
Bo NING
2
;
Xinyue ZHANG
1
;
Yuzhi HUO
1
;
Xinhui WU
1
;
Yuanhang YE
3
;
Fei WANG
1
Author Information
1. School of Clinical Medicine， Chengdu University of Traditional Chinese Medicine （TCM）， Chengdu 610032， China
2. Innovation Research Institute/Interdisciplinary Research Institute， Chengdu University of TCM， Chengdu 610093， China
3. Pengzhou Third People's Hospital， Pengzhou 611931， China
- Publication Type:Journal Article
- Keywords:
severe pneumonia;
signaling pathways;
traditional Chinese medicine;
research progress
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2025;31(8):294-302
- CountryChina
- Language:Chinese
-
Abstract:
Severe pneumonia is one of the most common and critical respiratory diseases in clinical practice. It is characterized by rapid progression， difficult treatment， high mortality， and many complications， posing a significant threat to the life and health of patients. The pathogenesis of severe pneumonia is highly complex， and studies have shown that its occurrence and development are closely related to multiple signaling pathways. Currently， the treatment of severe pneumonia mainly focuses on anti-infection， mechanical ventilation， and glucocorticoids， but clinical outcomes are often not ideal. Therefore， finding safe and effective alternative therapies is particularly important. In recent years， with the deepening of research into traditional Chinese medicine （TCM）， it has gained widespread attention in the treatment of severe pneumonia. This paper reviewed the relationship between severe pneumonia and relevant signaling pathways in recent years and how TCM regulated these pathways in the treatment of severe pneumonia. It was found that TCM could regulate the Toll-like receptor 4 （TLR4）/myeloid differentiation factor 88 （MyD88）/nuclear factor-κB （NF-κB）， Janus kinase （JAK）/signal transducer and activator of transcription （STAT）， phosphatidylinositol 3-kinase （PI3K）/protein kinase B （Akt）/mammalian target of rapamycin （mTOR）， NOD-like receptor protein 3 （NLRP3）， and nuclear factor E2-related factor 2 （Nrf2） signaling pathways， playing a role in reducing the inflammatory response， inhibiting cell apoptosis and pyroptosis， improving oxidative stress， and other effects in the treatment of severe pneumonia. Among these pathways， it was found that all of them regulated inflammation to treat severe pneumonia. Therefore， reducing inflammation is the core mechanism by which Chinese medicine treats severe pneumonia. This review provides direction for the clinical treatment of severe pneumonia and offers a scientific basis for the research and development of new drugs.
