Mechanism of HIF-1α in Diabetic Nephropathy and Improvement Effect of Traditional Chinese Medicine： A Review
10.13422/j.cnki.syfjx.20250106
- VernacularTitle:HIF-1α在糖尿病肾病中的机制研究及中医药改善作用的研究进展
- Author:
Jiarun XIE
1
;
Haoyu LIN
1
;
Xi CHEN
1
;
Jia SUN
2
;
Ming WANG
1
Author Information
1. School of Traditional Chinese Medicine，Southern Medical University，Guangzhou 510515，China
2. Zhujiang Hospital of Southern Medical University，Guangzhou 510280，China
- Publication Type:Journal Article
- Keywords:
diabetic nephropathy;
hypoxia;
hypoxia inducible factor-1 α（HIF-1α）;
metabolic regulation;
traditional Chinese medicine
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2025;31(8):287-293
- CountryChina
- Language:Chinese
-
Abstract:
In recent years， diabetic nephropathy （DN） has become an increasingly serious health challenge worldwide， and its morbidity and mortality rates are rapidly increasing. The patients suffering from the disease tend to be younger. DN is not only accompanied by a wide range of renal pathological changes， such as renal hypertrophy， inflammatory cell infiltration， expansion of the tethered membrane stroma， and thickening of the basement membrane but is also the main cause of end-stage renal disease and death in patients with diabetes mellitus. Therefore， it is particularly urgent to explore new strategies for the prevention and treatment of DN. The pathogenesis of DN is intricate and complex， with current research focusing on multifactorial interactions between metabolic and hemodynamic factors， such as hypoxia， inflammatory responses， and fibrotic processes. Notably， hypoxia plays a pivotal role in the initiation and progression of DN. Hypoxia-inducible factor （HIF-1α）， as a key regulatory protein commonly found in hypoxic cells， has a profound impact on various physiological and pathological processes， such as cell metabolism， vascular neogenesis， oxidative stress， and apoptosis. With its unique theoretical system and therapeutic approach， traditional Chinese medicine has demonstrated significant advantages in coping with hypoxic diseases and can slow down the progression of DN by regulating the expression level of HIF-1α and its downstream signaling molecules and exerting anti-inflammatory， antioxidant， and antifibrotic effects， which has positive clinical significance for drug development and early prevention and treatment of DN.
