Analysis and Discussion of Traditional Chinese Medicine and Compounds to Improve Diabetic Cardiomyopathy by Regulating Cardiomyocyte Pyroptosis
10.13422/j.cnki.syfjx.20250204
- VernacularTitle:中药及复方调控心肌细胞焦亡改善糖尿病心肌病的研究分析与探讨
- Author:
Ying ZHANG
1
;
Chengzhi XIE
1
;
Chang FU
1
;
Jianxun REN
1
Author Information
1. Institute of Basic Medical Sciences of Xiyuan Hospital， China Academy of Chinese Medical Sciences，Beijing 100091，China
- Publication Type:Review
- Keywords:
diabetic cardiomyopathy;
cardiomyocyte pyroptosis;
traditional Chinese medicine;
progress;
mechanism
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2025;31(8):260-267
- CountryChina
- Language:Chinese
-
Abstract:
Diabetic cardiomyopathy （DCM） is a myocardium-specific microvascular disease caused by diabetes mellitus that impairs the structure and function of the heart. It is the major cause of morbidity and mortality in diabetic individuals. Traditional Chinese medicine （TCM） has extensive clinical experience and precise efficacy in treating DCM， and its multi-target， multi-pathway， multi-component， and low side effect approach can slow the progression of DCM and improve the symptoms while effectively dealing with the complexity and long-term nature of its pathological process. Many recent studies have demonstrated that pyroptosis accompanied by inflammatory response is one of the main types of myocardial injury in DCM， which promotes the development of DCM and is closely related to pathological changes such as oxidative stress， myocardial fibrosis， myocardial hypertrophy， and decreased cardiac function in the course of DCM. These findings also provide a theoretical foundation for future research into potential therapy techniques and intervention mechanisms for DCM. By searching and analyzing relevant literature from several databases， including CNKI， PubMed， Web of Science， Excerpt Medica， Science Direct， and Springer， this study aimed to comprehensively analyze the characteristics of the effects of TCM and compounds in intervening in cardiomyocyte pyroptosis in DCM in recent years and explore the potential mechanisms. It also reveals the potential of effective components of TCM and compounds in preventing and controlling DCM from the standpoint of cardiomyocyte pyroptosis and provides a new way of thinking and more experimental evidence for the clinical application of TCM in treating DCM.
