Thoughts of Syndrome Differentiation and Treatment and Effect Mechanism of Haoqin Qingdantang in Treating Viral Pneumonia Based on Theory of Treating Different Diseases with Same Therapy
10.13422/j.cnki.syfjx.20250898
- VernacularTitle:基于“异病同治”理论探讨蒿芩清胆汤治疗病毒性肺炎的辨治思路及效应机制
- Author:
Xin PENG
1
;
Haotian XU
1
;
Lei LIANG
1
;
Zheyu LUAN
1
;
Hanxiao WANG
1
;
Yihao ZHANG
1
;
Kun YANG
1
;
Jihong FENG
2
Author Information
1. Tianjin University of Traditional Chinese Medicine，Tianjin 301617，China
2. The Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine，Tianjin 300250，China
- Publication Type:Journal Article
- Keywords:
treating different diseases with the same therapy;
Haoqin Qingdantang;
viral pneumonia;
thoughts of syndrome differentiation and treatment;
effect mechanism
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2025;31(8):209-217
- CountryChina
- Language:Chinese
-
Abstract:
The principle of treating different diseases with the same therapy is the essence of syndrome differentiation and treatment in traditional Chinese medicine （TCM）. It means that when the same pathogenic changes or the same symptoms appear in the development of different diseases， the same principles or methods can be used for treatment. Due to the complexity and high variability of viral pathogenicity， the precise and effective treatment of different types of viral pneumonia （VP） has always been a research focus and difficulty in modern medicine. VP belongs to the category of external-contraction febrile disease， warm disease， and epidemic in TCM. Haoqin Qingdantang （HQQDD） is a representative formula for clearing heat and dispelling dampness in warm diseases， and its intervention in VP caused by various viral infections has significant effects. This study， guided by the theory of treating different diseases with the same therapy， links the related studies on using HQQDD to treat different types of VP and finds that influenza virus pneumonia （IVP）， severe acute respiratory syndrome （SARS）， and COVID-19 all have a common pathogenic mechanism of dampness-heat at different stages of respective diseases. When these diseases are dominated by damp-heat factors， the use of HQQDD yields remarkable therapeutic effects. Modern pharmacological studies have confirmed that HQQDD can inhibit virus replication， reduce fever reactions， inhibit the expression of inflammatory mediators， and regulate immune balance. Moreover， the sovereign medicine in this formula has excellent antiviral activity， and the formula reflects rich scientific connotations of treating VP. According to the theory of treating different diseases with the same therapy and based on the effective treatment practice and modern pharmacological research of HQQDD for different types of VP， this paper mines the underlying TCM theory of treatment with the same therapy， explores the syndrome differentiation and treatment strategy and effect mechanism of this formula for different types of VP， and analyzes the treatment mechanism and characteristics， with the aim of providing evidence and reference for the clinical application and modern research of HQQDD.
