Research progresses on Keap1-Nrf2 pathway in inflammatory diseases
10.12206/j.issn.2097-2024.202405013
- VernacularTitle:Keap1-Nrf2通路在炎症疾病中的研究进展
- Author:
Wenyan ZHOU
1
;
Shanshan HU
1
;
Wannian ZHANG
2
;
Chunlin ZHUANG
2
Author Information
1. School of Pharmacy, Ningxia Medical University, Yinchuan 750004, China.
2. School of Pharmacy, Naval Medical University, Shanghai 200433, China.
- Publication Type:Reviews
- Keywords:
Keap1;
Nrf2;
mechanism of action;
inflammation;
inhibitor
- From:
Journal of Pharmaceutical Practice and Service
2025;43(3):97-108
- CountryChina
- Language:Chinese
-
Abstract:
The Keap1-Nrf2 pathway has been shown to be an important defense mechanism against oxidative stress, which may be an effective therapeutic strategy for many diseases. The research progresses on Keap1-Nrf2 pathway in inflammatory diseases were mainly reviewed. The basic components and activation mechanism of Keap1-Nrf2 pathway were introduced. The relationship between Keap1-Nrf2 pathway and the crosstalk between NF-κB pathway and HO-1 pathway, the expression of inflammatory mediators and enzymes, and inflammatory bodies were expounded. Natural product-derived inhibitors, small molecule inhibitors targeting Keap1-Nrf2 pathway and their clinical progress were introduced, and the potential application value of Keap1-Nrf2 pathway in the treatment of inflammation was discussed.
