Progress of Clinical and Pharmacological Mechanisms of Kidney-tonifying Formula for the Treatment of Alzheimer's Disease
10.19378/j.issn.1003-9783.2024.10.020
- VernacularTitle:补肾方剂治疗阿尔兹海默病的临床及药理机制研究进展
- Author:
Meng XIAO
1
;
Xiaolian ZHANG
;
Wei LIU
;
Jinna YANG
;
Wenjia WANG
;
Yunhui HU
;
Jiansong FANG
Author Information
1. 广州中医药大学科技创新中心,广东 广州 510405
- Keywords:
Alzheimer's disease;
kidney-tonifying formula;
clinical studies;
pharmacological research;
mechanism of action
- From:
Traditional Chinese Drug Research & Clinical Pharmacology
2024;35(10):1628-1636
- CountryChina
- Language:Chinese
-
Abstract:
Alzheimer's disease(AD) is a common neurodegenerative disease with increasing incidence rate. Up to now,there is no ideal treatment for AD. It has become a public health problem worldwide. Traditional Chinese medicine (TCM) believes that kidney deficiency is the key symptomatic element of deterioration and temporal progression symptoms,accompanied by the AD process. The treatment of tonifying kidneys,supplementing essence and replenishing marrow is the fundamental method for AD in TCM. Clinical studies have shown that kidney-tonifying formula can significantly improve the cognitive function and daily ability of patients with mild and moderate AD and have no obvious adverse reactions. Its mechanism of action may be related to the protection of nerves,reduction of β-amyloid (Aβ) level in the brain,inhibition of inflammatory factors activation and anti-oxidative stress. Besides reviewing the clinical and pharmacological research progress of kidney-tonifying formula for AD,this article also discusses the advantages and shortcomings of kidney-tonifying formula in the prevention and treatment of AD based on TCM theory and modern medical research. The aim of this study is to provide references of kidney nourishing therapy in TCM for the prevention and treatment of neurodegenerative diseases.
