Characteristics and Application Analysis of Animals Model of Cholelithiasis Based on Data Mining
10.19378/j.issn.1003-9783.2024.10.019
- VernacularTitle:基于数据挖掘的胆石症动物模型特点及应用分析
- Author:
Linlin WANG
1
;
Zhengwang ZHU
;
Jinghan ZHAO
;
Mingsan MIAO
;
Pingsheng ZHU
Author Information
1. 河南中医药大学,河南 郑州 450046
- Keywords:
Data mining;
cholelithiasis;
animal model;
clinical syndromes of traditional Chinese and western medicine;
combination of disease and syndrome
- From:
Traditional Chinese Drug Research & Clinical Pharmacology
2024;35(10):1621-1627
- CountryChina
- Language:Chinese
-
Abstract:
Objective To summarize the existing animal models of cholelithiasis,and to explore a pathological model that can better reflect the characteristics of clinical syndromes of traditional Chinese and western medicine and meet the needs of the development of clinical and basic research of traditional Chinese medicine. Methods The animal models for experimental research on cholelithiasis at home and abroad were collected and sorted out by searching CNKI,Wanfang,VIP,SinoMed,PubMed and other databases. The animal types,modeling methods,modeling cycles,detection indicators and positive drugs of the models were statistically analyzed. Results Among the 128 articles included,the animal types of cholelithiasis models were mainly guinea pigs,rabbits and C57BL/6J mice. The most used modeling method is high-fat diet,and the feeding cycle takes eight weeks to complete. High-frequency detection indicators were stone formation rate,total cholesterol,phospholipids,total bilirubin,total bile acid,etc. The commonly used intervention methods are traditional Chinese medicine compound,western medicine and single Chinese medicine or extract. Ursodeoxycholic acid (UDCA) is mainly used for western medicine intervention,whereas the intervention of traditional Chinese medicine mainly includes traditional Chinese medicine compound,acupuncture,exercise,diet and other methods. The positive control drug in the experiment was mostly UDCA. Conclusion With the continuous improvement and development of cholelithiasis animal model,there are many kinds of modeling methods to simulate the clinical manifestations of cholelithiasis in Chinese and western medicine,but there are also some limitations. This paper aims to provide reference for the selection,application and improvement of cholelithiasis model through data mining and characteristic analysis.
