Construction and Evaluation of Animal Model with Atherosclerosis and Phlegm-dampness Syndrome
10.19378/j.issn.1003-9783.2024.10.004
- VernacularTitle:动脉粥样硬化痰湿证动物模型的构建与评价
- Author:
Haiyang SUN
1
;
Zhixuan REN
;
Wen ZHAO
;
Xiao CHENG
;
Yan LI
;
Jingbo SUN
Author Information
1. 广州中医药大学第二临床医学院,广东广州 510006
- Keywords:
Atherosclerosis;
phlegm-dampness syndrome;
combination of disease and syndrome;
experimental animal model
- From:
Traditional Chinese Drug Research & Clinical Pharmacology
2024;35(10):1483-1491
- CountryChina
- Language:Chinese
-
Abstract:
Atherosclerosis(AS) is an important pathological feature of cardiovascular diseases such as myocardial infarction,stroke and other highly fatal diseases. Phlegm and dampness are considered to be an important pathogenesis of AS,which is difficult to heal and can cause complications. The establishment of an animal model with AS and phlegm-dampness syndrome,which could reflect the features of traditional Chinese medicine(TCM),and objective evaluation system are an important element of modern integrated TCM and western medicine research on cardiovascular diseases. It is of great significance for TCM to prevent and treat cardiovascular diseases. This article summarizes the scientific connotations of traditional Chinese and western medicine for AS and phlegm-dampness syndrome,comprehensively summarizes the current status of construction and evaluation in experimental animal model,analyzes the problems of current model,and discusses the factors of model construction and evaluation. Our aim is to establish normalized and standardized animal model with AS of phlegm-dampness syndrome.
