Exploring the Potential Target of Traditional Chinese Medicine for Improving Ferroptosis in Diabetic Nephropathy Based on Antioxidant Protein
10.19378/j.issn.1003-9783.2024.09.019
- VernacularTitle:基于抗氧化蛋白探讨中医药改善糖尿病肾病铁死亡的潜在靶点
- Author:
Jingye SUN
1
;
Wenze XIAO
;
Yanwen ZHOU
;
Haiying WANG
Author Information
1. 上海中医药大学中药学院,上海 201203
- Keywords:
Diabetic nephropathy;
ferroptosis;
antioxidant protein;
traditional Chinese medicine;
potential target
- From:
Traditional Chinese Drug Research & Clinical Pharmacology
2024;35(9):1445-1452
- CountryChina
- Language:Chinese
-
Abstract:
The pathogenesis of diabetic nephropathy(DN)is very complex.Ferroptosis as a kind of new way of cell death has become a research hotspot in recent years.It is widely known that DN is closely related to ferroptosis.Deactivation of system Xc--GSH-GPX4 axis,iron overload,lipid peroxidation and mitochondrial dysfunction play important role in occurrence and development of ferroptosis of DN,antioxidant protein may be a potential target for the treatment of ferroptosis of DN.Different pathways and interactions may alleviate the occurrence and development of ferroptosis by activating antioxidant protein such as GPX4,Nrf2,Sirtuin family protein and ferritin.Traditional Chinese medicine(TCM)has the characteristics of multi-component,multi-target and multi-pathway overall regulation.The active components and compounds of TCM have potential application value in improving renal injury and ferroptosis of DN by enhancing the expression of antioxidant protein,which provides a new research direction for delaying the progress of DN.
