Study on the Distribution of Traditional Chinese Medicine Syndrome Types and Medication Rules of Functional Dyspepsia Based on Data Mining
10.19378/j.issn.1003-9783.2024.09.018
- VernacularTitle:基于数据挖掘的功能性消化不良中医证型分布及用药规律研究
- Author:
Zhengwang ZHU
1
,
2
;
Linlin WANG
;
Jinghan ZHAO
;
Pingsheng ZHU
;
Mingsan MIAO
Author Information
1. 河南中医药大学,河南 郑州 450046
2. 豫药全产业链研发河南省协同创新中心,河南 郑州 450046
- Keywords:
Functional dyspepsia;
TCM syndrome types;
liver-stomach disharmony syndrome;
medication rules;
association rules;
factor analysis;
cluster analysis;
tonifying qi and strengthening spleen;
soothing liver and promoting qi circulation
- From:
Traditional Chinese Drug Research & Clinical Pharmacology
2024;35(9):1437-1444
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore syndrome differentiation of traditional Chinese medicine(TCM)and medication rules of functional dyspepsia,and to provide reference for modern TCM clinical treatment.Methods The clinical research literature on the treatment of functional dyspepsia with TCM were searched from CNKI,Wanfang,VIP,PubMed and Web of Science databases,TCM compounds were collected and database was established.Excel 2019,Clementine 12.0 and SPSS 21.0 were used for frequency analysis of TCM syndrome types,drug frequency,efficacy classifications,properties,tastes,and meridian tropisms of functional dyspepsia,and association rule analysis,factor analysis and cluster analysis were performed on high-frequency drugs.Results A total of 428 articles were included,and 442 prescriptions were extracted,involving 225 Chinese medicines and 24 high-frequency drugs,among which Codonopsis Radix,Poria,Citri Reticulatae Pericarpium and Bupleuri Radix were most frequently used.Tonic deficiency drugs and regulating qi drugs were the most common efficacy categories.The property was mainly warm,the tastes were mainly bitter,pungent and sweet,most of which belonged to spleen,lung and stomach meridians.Twenty drug combinations were obtained by association rule analysis,nine common factors were extracted by factor analysis,and drugs could be divided into four categories by cluster analysis.Functional dyspepsia with the liver-stomach disharmony is the most common syndrome.Twelve drug combinations were obtained by association rule analysis,three common factors were extracted by factor analysis,and drugs could be divided into two categories by cluster analysis.Conclusion The clinical treatment of functional dyspepsia in TCM is mainly to replenish qi and invigorate spleen,dredge liver and promote qi,replenish deficiency with sweet and warm drugs,disperse pungent and descend bitter,which were compatible with drugs for resolving dampness,relieving external symptoms and clearing heat according to syndrome differentiation.
