Characteristic Analysis of Animal Model of Trigeminal Neuralgia Based on Characteristics of Clinical Symptoms in Chinese and Western Medicine
10.19378/j.issn.1003-9783.2024.09.013
- VernacularTitle:基于中西医临床病症特点的三叉神经痛动物模型特点分析
- Author:
Yuqian LIU
1
;
Maoli LUO
;
Feipeng ZHU
;
Mingsan MIAO
Author Information
1. 河南中医药大学,河南 郑州 450046
- Keywords:
trigeminal neuralgia;
combination of disease and syndrome;
animal model;
Chinese and western medicine
- From:
Traditional Chinese Drug Research & Clinical Pharmacology
2024;35(9):1401-1407
- CountryChina
- Language:Chinese
-
Abstract:
Objective To construct an animal model with a high consistency of trigeminal neuralgia,this paper systematically reviewed and summarized the existing animal models based on the etiology and pathogenesis analysis of Chinese and western medicine,clinical diagnostic criteria and evaluation indexes of animal models.Methods Literatures on animal models of trigeminal neuralgia were consulted through CNKI and PubMed databases,the etiology and pathogenesis of Chinese and western medicine in the treatment of TN,diagnostic criteria of Chinese and western medicine,model replication objects in common animal models of trigeminal neuralgia,model replication methods and consistency of clinical manifestations of Chinese and western medicine were summarized and analyzed.Results At present,the most widely used model is the"infraorbital nerve injury"surgical model,which has high similarity in pathological manifestations with the clinical features of trigeminal neuralgia.Secondly,the chemical induction model of"penicillin injection"showed significant effect of inducing acute pain-like reactions.The photochemical induction model can effectively avoid the influence of factors such as tightness during surgical modeling process on the experimental results.Conclusion The current modeling method of integrated traditional Chinese and western medicine is still in the stage of exploration and has not formed a mature theoretical system.Therefore,we should actively invest more resources to develop animal models more closely related to traditiona Chinese medicine(TCM)syndromes in future research.The purpose is to provide strong theoretical basis and experimental support for the treatment of trigeminal neuralgia with integrated Chinese and western medicine.
