Research Progress in Pharmacological Effects of Tripterygium Wilfordii in the Treatment of Breast Cancer and Bone Metastasis
10.19378/j.issn.1003-9783.2024.08.019
- VernacularTitle:雷公藤治疗乳腺癌及其骨转移的药理研究进展
- Author:
Jing ZHANG
1
,
2
;
Jingwei LI
;
Zichao CHEN
;
Baohong LI
;
Yixuan ZOU
;
Hui LIU
;
Xiuyun ZHANG
;
Zhen ZHANG
Author Information
1. 山东中医药大学药学院,山东 济南 250355
2. 山东中医药大学中医药创新研究院,山东 济南 250355
- Keywords:
Tripterygium wilfordii;
active ingredients;
breast cancer;
bone metastasis;
vicious circle;
bone microenvironment
- From:
Traditional Chinese Drug Research & Clinical Pharmacology
2024;35(8):1272-1280
- CountryChina
- Language:Chinese
-
Abstract:
Breast cancer is one of the most prevalent malignant tumors.Bone metastasis is a common complication during the entire course of breast cancer.The vicious cycle of"tumor-bone microenvironment"was easily formed,which led to the occurrence of bone-related events such as bone pain,pathological fractures,and hypercalcemia,etc.Studies have found that active ingredients of Tripterygium wilfordii exhibit the effect of anti-breast cancer and regulation of bone microenvironment,including inhibition of tumor cell proliferation and migration,inhibition of tumor angiogenesis,induction of autophagy in tumor cells,regulation of bone formation in osteoblast cell,inhibition of bone resorption in osteoclast cell,promoting the differentiation of bone marrow mesenchymal stem cells into osteoblasts,and regulation of immune microenvironment,which may be helpful to inhibit breast cancer and bone metastasis.This article systematically reviewed the research progress on pharmacological effects of Tripterygium wilfordii in preventing breast cancer and bone metastasis,analyzed the limitations and application prospects of the current research.
