Research Progress on the Osteoimmunological Mechanism and Chinese Medicine Treatment of Ankylosing Spondylitis
10.19378/j.issn.1003-9783.2024.08.018
- VernacularTitle:强直性脊柱炎的骨免疫学机制及中医药治疗的研究进展
- Author:
Juanjuan YANG
1
;
Haolin LI
;
Zhendong WANG
;
Weigang CHENG
;
Jingjing SONG
;
Jin SU
;
Ping CHEN
;
Lili KAN
;
Fanghong NIAN
;
Haidong WANG
Author Information
1. 甘肃中医药大学中医临床学院,甘肃 兰州 730030
- Keywords:
Traditional Chinese medicine;
ankylosing spondylitis;
osteoimmunology;
mechanisms;
inflammatory response;
imbalance of bone metabolism
- From:
Traditional Chinese Drug Research & Clinical Pharmacology
2024;35(8):1264-1271
- CountryChina
- Language:Chinese
-
Abstract:
Ankylosing spondylitis(AS)is a chronic inflammatory autoimmune disease characterized by inflammatory back pain.Its pathological features mainly include inflammation,bone destruction,and pathologic new bone formation.The etiology of AS is complex,and it may be related to genetics,infections,the environment,and intestinal flora.Its pathogenesis has not yet been clarified.In recent years,osteoimmunology,as a new theme in the study of inflammatory arthritis,plays an important role in the pathogenesis and development of AS,which was embodied in the inflammatory response and imbalance of bone metabolism.Traditional Chinese medicine(TCM)has the characteristics of multiple pathways,multiple components,multiple targets and multiple levels.TCM can improve the inflammatory response and bone metabolism imbalance of AS by regulating the osteoblasts of the skeletal system and the related factors of the immune system,thus to prevent and control AS.For this reason,the paper summarizes the role of bone immunology in the pathogenesis of AS,and reviews the current status of research on the intervention of TCM in bone immunology for the treatment of AS,with a view to providing certain references for the future clinical application of TCM in the prevention and treatment of AS.
