Research Progress on the Mechanism of Regulating Glycolysis of Hepatic Stellate Cells Against Liver Fibrosis and the Prevention and Treatment of Traditional Chinese Medicine
10.19378/j.issn.1003-9783.2024.07.019
- VernacularTitle:调控肝星状细胞糖酵解抗肝纤维化的机制及中医药防治研究进展
- Author:
Mengmeng HAO
1
;
Lu LIU
;
Langping YI
;
Shuangwei LI
;
Xin CHEN
;
Hongying YANG
;
Minghuang GAO
;
Yousheng MO
;
Weirong LI
;
Qi WANG
Author Information
1. 广州中医药大学科技创新中心,广东 广州 510405
- Keywords:
hepatic stellate cells;
activation;
liver fibrosis;
glycolysis;
metabolic reprogramming;
traditional Chinese medicine;
active ingredients
- From:
Traditional Chinese Drug Research & Clinical Pharmacology
2024;35(7):1101-1106
- CountryChina
- Language:Chinese
-
Abstract:
Hepatic stellate cell(HSC)activation is a key link in the development of liver fibrosis.The metabolic reprogramming of activated HSC has become a hot topic in current research,especially the change of glycolysis is an important factor in regulating HSC activation.Based on the metabolic reprogramming in the process of HSC activation,this paper expounds the mechanism of regulating HSC activation and liver fibrosis through glycolysis,and reviews the research progress of traditional Chinese medicine and its active ingredients in regulating HSC glycolysis to prevent and treat liver fibrosis.Liver fibrosis is a complex pathological process involving multiple factors and pathways.From the perspective of regulating the glycolysis of activated HSC,it can provide a new idea for the development of anti-liver fibrosis drugs.
